Mrs Death has had enough. She is exhausted from spending eternity doing her job and now she seeks someone to unburden her conscience to. Wolf Willeford, a troubled young writer, is well acquainted with death, but until now hadn't met Death in person - a black, working-class woman who shape-shifts and does her work unseen.
Enthralled by her stories, Wolf becomes Mrs Death's scribe, and begins to write her memoirs. Using their desk as a vessel and conduit, Wolf travels across time and place with Mrs Death to witness deaths of past and present and discuss what the future holds for humanity. As the two reflect on the losses they have experienced - or, in the case of Mrs Death, facilitated - their friendship grows into a surprising affirmation of hope, resilience and love. All the while, despite her world-weariness, Death must continue to hold humans' fates in her hands, appearing in our lives when we least expect her . . .